In more than 950 scientific publications, Professor Edvinsson has described groundbreaking research that, among other results, has led to superior new drugs for migraine. Professor Edvinsson and his co-workers have published more than 300 scientific papers related to stroke.
Selected publications by Professor Edvinsson
1. Christensen ST, Johansson SE, Radziwon-Balicka A, Warfvinge K, Haanes KA, Edvinsson L. MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid hemorrhage in rats. PLoS ONE. 2019; 14: e0215398. https//doi.org10.1371/journal.pone.0215398
2. Mostajeran M, Wetterling F, W Blixt F, Edvinsson L, Ansar S. Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging. Acta Physiologica. 2018; 223(1):e12985. https://doi.org/10.1111/apha.12985
3. Spray S, Johansson SE, Edwards AVG, Larsen MR, Radziwon-Balicka AI, Povlsen GK et al. Alterations in the cerebral microvascular proteome expression profile after transient global cerebral ischemia in rat. Journal of Molecular Neuroscience. 2017; 61(3):396-411. https://doi.org/10.1007/s12031-016-0875-8
4. Spray S, Johansson SE, Radziwon-Balicka A, Haanes KA, Warfvinge K, Povlsen GK et al. Enhanced contractility of intraparenchymal arterioles after global cerebral ischemia in rat - new insights into the development of delayed cerebral hypoperfusion. Acta Physiologica. 2017; 220(4):417-431. https://doi.org/10.1111/apha.12834
5. Povlsen GK, Edvinsson L. MEK1/2 inhibitor U0126 but not endothelin receptor antagonist clazosentan reduces upregulation of cerebrovascular contractile receptors and delayed cerebral ischemia, and improves outcome after subarachnoid hemorrhage in rats. J Cereb Blood Flow Metab. 2015;35:329-337. https://doi.org/10.1038/jcbfm.2014.205
6. Edvinsson L, Larsen SS, Maddahi A, Nielsen J. Plasticity of cerebrovascular smooth muscle cells after subarachnoid hemorrhage. Translational Stroke Research. 2014 Jun;5(3):365-76. https://doi.org/10.1007/s12975-014-0331-4
7. Samraj AK, Müller AH, Grell A-S, Edvinsson L. Role of unphosphorylated transcription factor STAT3 in late cerebral ischemia after subarachnoid hemorrhage. J Cereb Blood Flow Metab. 2014;34(5):759-63. https://doi.org/10.1038/jcbfm.2014.15
8. Johansson SE, Larsen SS, Povlsen GK, Edvinsson L. Early MEK1/2 inhibition after global cerebral ischemia in rats reduces brain damage and improves outcome by preventing delayed vasoconstrictor receptor upregulation. PLoS ONE. 2014; 9(3):e92417. https://doi.org/10.1371/journal.pone.0092417
9. Parker B, Larsen MR, Edvinsson LIH, Povlsen GK. Signal transduction in cerebral arteries after subarachnoid hemorrhage - a phosphoproteomic approach. J Cereb Blood Flow Metab. 2013;33(8):1259-69. https://doi.org/10.1038/jcbfm.2013.78
10. Povlsen GK, Johansson SE, Larsen CC, Samraj AK, Edvinsson L. Early events triggering delayed vasoconstrictor receptor upregulation and cerebral ischemia after subarachnoid hemorrhage. BMC Neuroscience. 2013; 14:34. https://doi.org/10.1186/1471-2202-14-34
11. Ansar S, Eftekhari S, Waldsee R, Nilsson E, Nilsson O, Säveland H et al. MAPK signaling pathway regulates cerebrovascular receptor expression in human cerebral arteries. BMC Neuroscience. 2013; 14:12. https://doi.org/10.1186/1471-2202-14-12
12. Maddahi A, Povlsen G, Edvinsson L. Regulation of enhanced cerebrovascular expression of proinflammatory mediators in experimental subarachnoid hemorrhage via the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway. J Neuroinflammation. 2012; 9:274. https://doi.org/10.1186/1742-2094-9-274
13. Ahnstedt H, Säveland H, Nilsson O, Edvinsson L. Human cerebrovascular contractile receptors are upregulated via a B-Raf/MEK/ERK- sensitive signaling pathway. BMC Neuroscience. 2011; 12:5. https://doi.org/10.1186/1471-2202-12-5
14. Larsen CC, Povlsen GK, Rasmussen MNP, Edvinsson L. Improvement in neurological outcome and abolition of cerebrovascular endothelin B and 5-hydroxytryptamine 1B receptor upregulation through mitogen-activated protein kinase kinase 1/2 inhibition after subarachnoid hemorrhage in rats. J Neurosurgery. 2011; 114(4):1143-53. https://doi.org/10.3171/2010.6.JNS1018
15. Ansar S, Maddahi A, Edvinsson L. Inhibition of cerebrovascular raf activation attenuates cerebral blood flow and prevents upregulation of contractile receptors after subarachnoid hemorrhage. BMC Neuroscience. 2011; 12:107. https://doi.org/10.1186/1471-2202-12-107
16. Edvinsson L, Povlsen GK. Late cerebral ischaemia after subarachnoid hemorrhage: is cerebrovascular receptor upregulation the mechanism behind? Acta Physiologica. 2011; 203(1):209-24. https://doi.org/10.1111/j.1748-1716.2010.02227.x
17. Edvinsson LIH, Povlsen GK. Vascular plasticity in cerebrovascular disorders. J Cereb Blood Flow Metab. 2011; 31(7):1554-71. https://doi.org/10.1038/jcbfm.2011.70
18. Spray S, Haanes KA, Edvinsson L, Johansson SE. Subacute phase of subarachnoid hemorrhage in female rats: Increased intracranial pressure, vascular changes and impaired sensorimotor function. Microvasc Res. 2021; 135:104127. https://doi: 10.1016/j.mvr.2020.104127
19. Rehnström M, Frederiksen SD, Ansar S, Edvinsson L.. Transcriptome profiling revealed early vascular smooth muscle cell gene activation following focal ischemic stroke in female rats - comparisons with males. BMC Genomics. 2020; 21(1): 883. https://doi: 10.1186/s12864-020-07295-2